National Security Applying world-class technologies to scientific issues of national importance Read more about proliferation detection >> Cognitive Simulation Integrating new techniques to gain insight into mission-oriented and scientific simulations Read more about cognitive simulation >> Precision Medicine Understanding and predicting human response to disease, drugs, and biological threats Read more about precision medicine >> Basic Science Advancing the scientific foundations of broad research areas for new discoveries Read more about astrophysics, Earth system research, and interpretable machine learning >> Materials & Advanced Manufacturing Accelerating materials discovery and optimization for rapid deployment of materials Read more about materials >> Energy Investigating energy use and applications while reducing environmental impact Read more about power grid resilience >>